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Effect of high flow oxygen therapy on respiratory function following upper abdominal surgery

Effect of high-flow nasal oxygen therapy on diaphragmatic function and lung aeration after upper abdominal surgery; a randomized controlled trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/12/029680
Enrollment
60
Registered
2020-12-09
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Y839- Surgical procedure, unspecified asthe cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

Interventions

Intervention1: High-flow nasal oxygen therapy: Supplemental oxygen therapy will be delivered via High-flow nasal cannula at an initial FiO2 of 0.5 and a flow rate of 50%.FiO2 will be titrated to maint

Sponsors

Vimi Rewari
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1)ASA grade 1 and 2 patients. 2)Able to understand verbal instructions and provide informed consent. 3)Undergoing elective upper abdominal surgery , involving an abdominal incision longer than 5 cm that is above or extending above the umbilicus.

Exclusion criteria

Exclusion criteria: 1) Patient refusal to participate in the study 2) Patients undergoing emergency laparotomy 3) Patients with tracheostomy, pleural effusion, pneumothorax, pulmonary atelectasis, k/c/o COPD/Restrictive lung disease 4) Intra operative massive blood loss( >40 ml/kg)/ massive transfusion( >8 PRBC during Surgery) 5) Known deformity of chest wall or thoracic spine . 6) Patients with history of previous thoracic surgery 7) BMI >30 kilograms per meter square. 8)Obstructive Sleep apnea

Design outcomes

Primary

MeasureTime frame
To evaluate the effect of HFNO2 on inspiratory diaphragmatic excursion after upper abdominal surgeryTimepoint: Preoperatively, 2 hours after extubation and 24 hours after extubation—

Secondary

MeasureTime frame
1)To evaluate the effect of HFNO2 on lung aeration as assessed by Lung Ultrasound Score 2)To evaluate the effect of HFNO2 on post operative oxygenation as assessed by PaO2/FiO2 ratio 3) To determine the clinical variables associated with post operative diaphragmatic dysfunction and loss of lung aeration. 4)To determine the correlation of diaphragmatic dysfunction with - Lung ultrasound scores - PaO2/FiO2 ratio - Body mass index - Age - Duration of surgeryTimepoint: Preoperatively, 2 hours after extubation and 24 hours after extubation—

Countries

India

Contacts

Public ContactGurudarshan S

All India Institute of Medical Sciences

vimirewari@gmail.com9999247802

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026