Health Condition 1: J09-J18- Influenza and pneumonia Health Condition 2: J22- Unspecified acute lower respiratory infection
Conditions
Interventions
Intervention1: Positive expiratory pressure - oxygen therapy trial: Duration of therapy: 45 minutes.
Patients on standard oxygen therapy will be put on positive expiratory pressure-oxygen therapy sup
Sponsors
AIIMS Delhi
Eligibility
Inclusion criteria
Inclusion criteria: Patients, aged 10-55 years on standard oxygen therapy for at least 1 hour with features of respiratory distress, with stability on current support. Respiratory distress defined as either of following: 1. Respiratory rate � 24/minute 2. SpO2 at current support 3. Features of accessory muscle use (intercostal retractions, nasal flaring)
Exclusion criteria
Exclusion criteria: 1. Acute exacerbation of asthma or chronic obstructive pulmonary disease. 2. Impending respiratory failure (features of exhaustion, or SpO2 3. Poor respiratory efforts (muscular weakness, or reduced central drive) 4. Patients with chronic or acute hypercapnia (PaCO2 >45) 5. Hemodynamically unstable (Hypotension or requirement of inotropic support) 6. Altered sensorium (Glasgow Coma Scale < 15)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportions of patients tolerating PEP-OTTimepoint: At 15 minutes, 30 minutes and 45 minutes of PEP-OT | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in respiratory and cardiovascular parameters after starting PEP-OTTimepoint: every 15 minutes over 45 minutes of PEP-OT trial, followed by 15 minutes following completion of PEP-OT trial;Incidence of adverse events of PEP-OTTimepoint: continuously over 45 minutes of PEP-OT trial and 15 minutes following PEP-OT trial | — |
Countries
India
Contacts
Public ContactRakesh Lodha
AIIMS, Delhi
Outcome results
None listed