Health Condition 1: K089- Disorder of teeth and supporting structures, unspecified Health Condition 2: M264- Malocclusion, unspecified
Conditions
Interventions
Intervention1: Recent extraction sites in orthodontic patients: Retraction of anterior teeth immediately following extraction of upper or lower first premolar ( initiation of retraction forces on the
Sponsors
All India Institute of Medical Sciences Jodhpur
Eligibility
Inclusion criteria
Inclusion criteria: 1) Patient requiring extraction of 4 premolars for correction(class II div.1 malocclusion, Bimaxillary protrusion) 2) Patient above 12 years of age 3) Need for fixed appliance therapy involving tooth extractions, good general and periodontal health 4) Good oral hygiene 5) Full permanent dentition including the maxillary second molars
Exclusion criteria
Exclusion criteria: 1) Pregnancy and lactation 2) Patients who would not give informed consent 3) Patients consuming alcohol or tobacco use. 4) Any systemic condition that could affect periodontal status 5) Previous history of orthodontic treatment 6) Patient with disorders of bone metabolism (e.g., osteoporosis, gastrointestinal diseases related to nutrition and mineral metabolism, endocrine diseases, immunologic disorders, and connective tissue diseases) 7) Patient already under medication for treatment of conditions like heart conditions, joint replacements, hormonal or bisphosphonate antiresorptive therapies, and chronic therapy with heparin or corticosteroids. 8) Patients with developmental anomalies like, cleft lip and palate and other craniofacial abnormalities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Salivary levels of RANKL and OPG will be measured through an ELISA-based capture assay by using the commercial kits (Bioassay™ technology laboratory) HUMAN RANKL ELISA and OPG ELISA (At Biochemistry laboratory, AIIMS JODHPUR) following the manufacturer’s instructionsTimepoint: concentration will be measured in these time points; before bonding (T0), after levelling and alignment and just before application of retraction force (T1), 2 weeks after application of retraction force (T2), 6-7 weeks after application of retraction force (T3) and 10-11 weeks after application of retraction force | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of tooth movement will be calculated clinically, in terms of distance between cusp tip of maxillary canines and mesiobuccal cusp tips of maxillary first molars, with the help of vernier caliperTimepoint: Alginate impression will be taken at given time poins before bonding (T0), after levelling and alignment and just before application of retraction force (T1), 2 weeks after application of retraction force (T2), 6-7 weeks after application of retraction force (T3) and 10-11 weeks after application of retraction force | — |
Countries
India
Contacts
Public ContactVaghela Niraj Himmatlal
All India Institute of Medical Sciences Jodhpur
Outcome results
None listed