FindTrial
Sign In

A clinical trial to compare the levels of sclerostin and ICTP in periodontitis patients

TO EVALUATE THE LEVELS OF SCLEROSTIN AND C-TELOPEPTIDE PYRIDINOLINE CROSS LINKS (ICTP) IN GCF AND SERUM OF GINGIVITIS AND STAGE II TO STAGE III PERIODONTITIS PATIENTS: A COMPARATIVE ANALYTICAL STUDY.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/12/029657
Enrollment
45
Registered
2020-12-09
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Evaluating serum and GCF levels of sclerostin and C-TELOPEPTIDE PYRIDINOLINE CROSS LINKS molecules: Collection of GCF and serum in healthy, gingivitis and periodontitis patients to eval

Sponsors

Rajarajeswari Dental College and Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult males and females who were diagnosed with healthy,gingivitis and stage II to stage III periodontitis patients. Group 1 : Healthy controls 1. No sites with probing depth >=4mm or clinical attachment loss >=1mm. 2 .Patient who do not show any gingival disease with a gingival index score Group 2 : Gingivitis 1. No sites with probing depth >=3mm. 2. Clinical attachment loss 3. Patient who exhibited > 20 sites with BOP. 4. Patient who show gingival disease with a gingival index score >1. Group 3 : Stage II to Stage III Periodontitis. 1. Clinical attachment loss >= 5mm. 2. Radiographic evidence of alveolar bone loss extending to middle third of root and beyond. 3. Tooth loss 4. Probing depths>= 6mm.

Exclusion criteria

Exclusion criteria: 1. Patients with history of systemic diseases. 2. Smokers and alcoholic patients. 3. Patients on any medication taken within 6 months which may alter the clinical parameters of the study. 4. Pregnant and lactating women. 5. Patients who have undergone periodontal treatment within a period of last 1 year.

Design outcomes

Primary

MeasureTime frame
â?¢Gingival index (GI) (Loe H and Silness - 1963). â?¢Probing pocket depth (PPD) measured using graduated Williams periodontal probe from the crest of gingival margin to base of the pocket. â?¢Periodontal index (PI) (Russell -1956). Timepoint: At baseline—

Secondary

MeasureTime frame
â?¢Gingival index (GI) (Loe H and Silness - 1963). â?¢Probing pocket depth (PPD) measured using graduated Williams periodontal probe from the crest of gingival margin to base of the pocket. â?¢Periodontal index (PI) (Russell -1956). Timepoint: At baseline—

Countries

India

Contacts

Public ContactASHA V

Rajarajeswari Dental College and hospital

dr.s.savita@gmail.com9845446437

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026