Health Condition 1: A499- Bacterial infection, unspecified
Conditions
Interventions
Intervention1: Outpatient treatment with oral Amoxicillin: Syrup Amoxicillin (oral) BD x 5 days
Control Intervention1: Inpatient treatment with Inj Gentamicin and Inj Ampicillin: Inj Gentamicin OD x 5
Sponsors
Centre for Health Research and Development Society for Applied Studies
Eligibility
Inclusion criteria
Inclusion criteria: All patients admitted to the study hospitals with relatively higher-mortality risk signs of CSI at presentation (not feeding well, movement only on stimulation, low body temperature 1. Clinically well on day 3 defined as absence of all signs of critical illness (not feeding at all, no movement at all, convulsions) or CSI (not feeding well, movement only when stimulated, low body temperature ( =38oC), severe chest indrawing, fast breathing in 2. Laboratory test negative, and 3. Family lives within a catchment area where a follow-up of up to day 15 can be accomplished.
Exclusion criteria
Exclusion criteria: 1. Weight 2. Signs of critical illness on admission (no movement at all, unable to feed at all, or convulsions), or 3. Appearance of any high-mortality risk sign or multiple low-mortality risk signs in first 24 hours of life, or 4. Hospitalized for any illness in the previous 2 weeks, or 5. Prior use of injectable antibiotics for the same illness, or 6. Previously included in this study or currently included in any other study, or 7. Any other reason to stay in hospital, as decided by the treating physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Death Presence of any sign of critical illness or sign suggestive of another serious infection Presence of any sign of CSITimepoint: Randomization to Day 15 Day 8 Day 8 | — |
Secondary
| Measure | Time frame |
|---|---|
| Not knownTimepoint: Not known | — |
Countries
India
Contacts
Public ContactTemsunaro Rongsen Chandola
Centre for Health Research and Development, Society for Applied Studies
Outcome results
None listed