Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: nil: Heparin 5000U/ml intravenous formulation will be diluted with 3 ml of 0.9% normal saline, and all critical patients meeting inclusion and exclusion criteria will be nebulised every
Sponsors
Department of anaesthesiology AIIMS Rishikesh
Eligibility
Inclusion criteria
Inclusion criteria: Age 18 years or older, with Endotracheal tube or Noninvasive ventilation in place, intubated/put on NIV yesterday or today with PaO2 to FIO2 ratio less than or equal to 300
Exclusion criteria
Exclusion criteria: 1. Heparin allergy or heparin-induced thrombocytopaenia 2. APTT > 120 seconds and this is not due to anticoagulant therapy 3. Platelet count 4.Pulmonary bleeding, which is frank bleeding in the trachea, bronchi or lungs with repeated haemoptysis or requiring repeated suctioning 5. Uncontrolled bleeding 6. Pregnant or suspected pregnancy (Urine or serum HCG will be recorded) 7. Receiving or about to commence ECMO or HFOV 8. Death is imminent or inevitable within 24 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Outcome Measures: 1. D-dimer profile [ Time Frame: Up to day 10 days. ] 2. NLR ratio [Time frame up to 10 days] 3. Mean daily PaO2 to FiO2 ratio [ Time Frame: 10 days ] Timepoint: Primary Outcome Measures: 1. D-dimer profile [ Time Frame: Up to day 10 days. ] 2. NLR ratio [Time frame up to 10 days] 3. Mean daily PaO2 to FiO2 ratio [ Time Frame: 10 days ] | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Oxygenation Index, as assessed by Po2 2. Quasi-Static Lung Compliance [ Time Frame: Up to day 10] Determine the effect of nebulised heparin on Quasi-Static Lung Compliance (i.e. tidal volume/(Plateau pressure-PEEP) 3. Time to separation from invasive ventilationTimepoint: day 1,3 and 10 | — |
Countries
India
Contacts
Public ContactBhavna Gupta
AIIMS hospital, Rishikesh
Outcome results
None listed