Health Condition 1: N200- Calculus of kidney
Conditions
Interventions
Intervention1: Tab.Tapentadol: 100mg once per oral one hour prior to surgery
Intervention2: Tab.Pregabalin: 75mg once per oral one hour prior to surgery
Intervention3: Tab.Solifenacin: 5mg once per o
Sponsors
NONE
Eligibility
Inclusion criteria
Inclusion criteria: Patients of either sex Aged 18 â?? 60 years Patients of American Society of Anaesthesiologists grade I & II Scheduled for elective percutaneous nephrolithotomy under general anaesthesia.
Exclusion criteria
Exclusion criteria: Age 60 years Patients of American Society of Anaesthesiologists grade III & IV History of significant cardiac diseases like previous MI, arrhythmias, high A V conduction blocks, uncontrolled hypertension, angina. History of chronic use of beta-blockers Sleep apnoea Significant liver dysfunction History of chronic opioid use, Patients with renal failure ( higher serum creatinine levels >=1.5mg%, urine 3 at night or >8 in 24 hours) / transurethral resection of prostate for benign prostatic hyperplasia Hypersensitivity to any of the study drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of preoperative oral administration of tapentadol, pregabalin and solifenacin on the prevalence and severity of catheter related bladder discomfort in patients undergoing percutaneous nephrolithotomyTimepoint: Severity of CRBD will be evaluated by a blinded assessor at intervals of 0, 1, 2, 4, 6, 12, 24 hours postoperatively on four point severity scale | — |
Secondary
| Measure | Time frame |
|---|---|
| NONETimepoint: NA | — |
Countries
India
Contacts
Public ContactProf Sanjay agrawal
All India Institute of Medical Sciences Rishikesh
Outcome results
None listed