Health Condition 1: H041- Other disorders of lacrimal gland
Conditions
Interventions
Intervention1: Intra glandular injection of 5- fluorouracil: 2.5mg injected every 4 weeks until there is no further improvement. The injections would continue depending upon the clinical scenario, or
Sponsors
L V Prasad Eye Institute
Eligibility
Inclusion criteria
Inclusion criteria: 1) Age more than 12 years 2) Patients diagnosed with cicatrizing conjunctivitis or Stevens-Johnson syndrome or Ocular cicatricial pemphigoid having Schirmer I value between 1-5mm 3) If both eyes match the criteria, then eye with less Schirmer value would be chosen 4) Only those who choose the injection modality and give a valid consent (attached) will be enrolled into the study.
Exclusion criteria
Exclusion criteria: 1) Presence of corneal epithelial defects 2) Schirmer value of zero mm 3) Any ocular surgery within past 3 months 4) Any keratoplasty or ocular surface procedure performed during the trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. BCVA 2. Ocular surface disease index 3. Schirmer I value (without anesthesia) 4. Corneal and conjunctival hyperemia 5. Corneal epithelial fluorescein staining 6. Slit lamp images- unstained, fluorescein, green filter 7. Tear sampling for future proteomic study Timepoint: 1 and 3 months from the last injection | — |
Secondary
| Measure | Time frame |
|---|---|
| Corneal and conjunctival hyperemia Corneal epithelial fluorescein staining Visual acuityTimepoint: Monthly for one year | — |
Countries
India
Contacts
Public ContactDrSwati Singh
L V Prasad Eye Institute
Outcome results
None listed