Health Condition 1: F202- Catatonic schizophrenia Health Condition 2: F201- Disorganized schizophrenia Health Condition 3: F208- Other schizophrenia Health Condition 4: F200- Paranoid schizophrenia Health Condition 5: F205- Residual schizophrenia Health Condition 6: F209- Schizophrenia, unspecified Health Condition 7: F203- Undifferentiated schizophrenia
Conditions
Interventions
Intervention1: BILATERAL CONTINUOUS THETA BURST TRANSCRANIAL MAGNETIC STIMULATION: Bilateral continuous theta burst transcranial magnetic stimulation will be delivered for two sessions (bilateral
left and then right temporoparietal area consecutively) daily for 5 days for a week for 2 consecutive weeks.
Control Intervention1: PLACEBO: Then placebo treatment will be delivered for two sessions (
left and then right temporoparietal area consecutively) daily for 5 days for a week for 2 consecutive weeks.
Sponsors
SRI GURU RAM RAI INSTITUTE OF MEDICAL AND SCEINCES
Eligibility
Inclusion criteria
Inclusion criteria: 1.) Patients must fulfill the diagnostic criteria of schizophrenia as per ICD-10 DCR (Diagnostic criteria for research). 2.) Age: between 18-59 years. 3.) Right-handed patients. 4.) Severity of AVH: score of 3 or more according to Positive and Negative Syndrome Scale (PANSS). 5.) Inadequate response (remission of AVH) to at least one antipsychotic drug at maximally tolerated dose, which is within the recommended therapeutic range, in trials lasting 6 weeks or more. 6.) Stable antipsychotic medication 4 weeks before and during the continuous theta burst transcranial magnetic stimulation treatment.
Exclusion criteria
Exclusion criteria: 1.) History suggestive of brain injury or surgery. 2.) Any significant brain malformation/neoplasm. 3.) Neurodegenerative disorder or history of seizures. 4.) History of ECT within the past 6 months. 5.) Pacemakers of other metal parts in the body. 6.) Diagnosis of mental and behavioural disorder due to use of psychoactive substances harmful use or dependence (except nicotine and caffeine).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| For assessing improvement in auditory verbal hallucinations and therapeutic response, following scales to be used-PANSS(positive and negative syndrome scale) AVHRS(auditory vocal hallucination rating scale) PSYRATS-AH(psychotic symptom rating scales- auditory hallucinations scale) CGI(clinical global impression) Timepoint: PANSS, AVHRS, PSYRATS-AH and CGI ratings will be applied at the beginning of TMS, end of TMS and post 2 weeks of TMS (i.e. baseline, 15th day and 30th day). | — |
Secondary
| Measure | Time frame |
|---|---|
| CDSS(calgary depression scale for schizophrenia) for assessing level of depression in schizophrenia. SCoRS(schizophrenia cognition rating scale manual) for evaluation of cognitive deficits in schizophrenia. Timepoint: CDSS and SCoRS ratings will be applied at the beginning of TMS, end of TMS and post 2 weeks of TMS (i.e. baseline, 15th day and 30th day). | — |
Countries
India
Contacts
Public ContactPRIYA TYAGI
SRI GURU RAM RAI INSTITUTE OF MEDICAL AND HEALTH SCIENCES
Outcome results
None listed