Health Condition 1: G610- Guillain-Barre syndrome
Conditions
Interventions
Intervention1: Therapeutic Plasma Exchange: TPE will be performed on automated cell separator: Spectra Optia® (Terumo BCT Lakewood, CO) after an informed consent from patientsâ?? parents/guardians. P
Sponsors
Manjinder Singh Randhawa
Eligibility
Inclusion criteria
Inclusion criteria: 1. Admitted with a diagnosis of Landry Guillain Barre Syndrome 2. Requiring Mechanical Ventilation 3. Presentation <14 days from onset of symptoms
Exclusion criteria
Exclusion criteria: 1. Treatment with IvIg or PE prior to admission 2. History of prior episode of LGBS 3. Patients with known malignancy, AIDS, IgA deficiency 4. Patients with a known chronic neurological/neuromuscular disorder 5. Patients with a known Renal Failure/Cardiac dysfunction 6. Patients with a history of a transfusion reaction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the mean duration of mechanical ventilation among ventilated children less than12 years of age with Landry Guillain Barre Syndrome who undergo Therapeutic Plasma Exchange (5 Cycles) with those who receive Intravenous Immunoglobulin (@ 2g/kg)Timepoint: To compare the mean duration of mechanical ventilation among ventilated children less than12 years of age with Landry Guillain Barre Syndrome who undergo Therapeutic Plasma Exchange (5 Cycles) with those who receive Intravenous Immunoglobulin (@ 2g/kg) | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse Effects of therapy in the two groupsTimepoint: Till discharge/death;All Cause MortalityTimepoint: Till discharge/death;Duration of PICU stayTimepoint: Continuous variable;Functional score (Hughes Score)Timepoint: At PICU discharge, Hospital discharge and 3 months;Healthcare Associated InfectionsTimepoint: Till discharge/death;Time to improvement of one grade in Hughes scoreTimepoint: Continuous variable;Time to walk unaidedTimepoint: Continuous variable | — |
Countries
India
Contacts
Public ContactManjinder Singh Randhawa
Post Graduate Institute of Medical Education and Research
Outcome results
None listed