Health Condition 1: I219- Acute myocardial infarction, unspecified
Conditions
Interventions
Intervention1: To evaluate the changes in Left ventricular dimensions and function in extensive myocardial infarction (MI) patients on SGLT2 inhibitors.
: a) To compare the improvement in left ventric
Sponsors
Department of Cardiology Kasturba Medical College and Hospital Manipal
Eligibility
Inclusion criteria
Inclusion criteria: 1. Extensive MI 2. LVEF 3. Diagnosed with T2DM, defined as: • Prior documentation of type 2 diabetes AND/OR • Treatment with anti-hyperglycemic medications and/or diet AND/OR • ADA criteria: fasting >126 mg/dl (7.0 mmol/L) or HbA1C >=6.5% or 2-h plasma glucose>=200 mg/dl (11.1 mmol/L) during an oral glucose tolerance test, or a random plasma glucose >= 200 mg/dL (11.1 mmol/L) in patients with classic symptoms of hyperglycemia or hyperglycemic crisis. 4. Creatinine clearance of 30 ml or more per minute. 5. Patients on optimal antidiabetic therapy of oral hypoglycemic agents including SGLT2 inhibitors and/or insulin. 6. On optimal therapy post MI including dual antiplatelets, statins,beta blockers/ARBâ??s/ACE inhibitors, aldosterone antagonists and/or diuretics, if tolerated.
Exclusion criteria
Exclusion criteria: 1. Severe infection 2. Serious liver or renal functional failure (estimated glomerular filtration rate [eGFR] 3. Alcohol dependency or use of illicit drugs 4. Pregnant or breastfeeding, possibly pregnant, or planning to become pregnant in the study period (female patients only) 5. Dehydration (abnormal hematocrit [Ht] and blood urea nitrogen, symptoms of dehydration);urinary tract or genital infection 6. History of hypersensitivity to the study drugs 7. Severe ketosis, diabetic coma or precoma 8. Ongoing or past history of pancreatitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measured in this study will be change in LV mass index from baseline to mean of 3-6 months at follow up. Secondary outcomes include changes in Left Ventricular Ejection fraction Area Length Ejection Fraction (ALEF) Left ventricular End Diastolic Volume and index Left ventricular End Systolic Volume and index E/E: ratio between early mitral inflow velocity and mitral annular early diastolic velocity Left atrial volume and Index LV contractility dp/dt Timepoint: 0 AND 6 MONTHS | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include changes in Left Ventricular Ejection fraction Area Length Ejection Fraction (ALEF) Left ventricular End Diastolic Volume and index Left ventricular End Systolic Volume and index E/E: ratio between early mitral inflow velocity and mitral annular early diastolic velocity Left atrial volume and Index LV contractility dp/dtTimepoint: 0 AND 6 MONTHS | — |
Countries
India
Contacts
Public ContactJIJIN SATHEESH
Katurba Medical College
Outcome results
None listed