Health Condition 1: E101- Type 1 diabetes mellitus with ketoacidosis
Conditions
Interventions
Intervention1: Administration of 0.9% normal saline, ringer lactate: Administration of 0.9% normal saline, ringer lactate in children with diabetic ketoacidosis
Control Intervention1: nil: no comparat
Sponsors
Post Graduate Institute of Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: All children with diabetic ketoacidosis will be taken as study participants
Exclusion criteria
Exclusion criteria: Children with underlying liver disorders Children with pre-existing/ established renal disease children with symptomatic cerebral edema children with diagnosed or suspected inborn error of metabolism children with serum potassium more than 5.5meq/litre at admission
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to resolution of acidosis(pH 7.3 and bicarbonate 15mmol/l), sensorium and closure of anion gapTimepoint: Time to resolution of acidosis(pH 7.3 and bicarbonate 15mmol/l), sensorium and closure of anion gap | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in chloride levels pH Bicarbonate levels Incidence of hypokalemia and hypoglycemia in the two groups Total amount of fluid received in two groups incidence of new onset or progression of acute kidney injury in two groups Proportion of children requiring renal replacement therapy in two groups proportion of in hospital all cause mortality comparison of length of ICU/hospital stay cost analysis of interventionTimepoint: upto 28 days of enrollment | — |
Countries
India
Contacts
Public ContactJayshree Muralidharan
Post Graduate Institute of Medical Education and Research Chandigarh
Outcome results
None listed