Skip to content

Comparison of Propofol, Etomidate and a combination of both on the hemodynamic response

Comparative evaluation of Effect of Propofol, Etomidate and a combination of Propofol and Etomidate on the hemodynamic response to induction and endotracheal intubation: a prospective randomized double blinded study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/11/029445
Enrollment
126
Registered
2020-11-27
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K802- Calculus of gallbladder without cholecystitis Health Condition 2: N200- Calculus of kidney Health Condition 3: K469- Unspecified abdominal hernia without obstruction or gangrene Health Condition 4: K37- Unspecified appendicitis Health Condition 5: S529- Unspecified fracture of forearm Health Condition 6: H729- Unspecified perforation of tympanic membrane

Interventions

Intervention1: Group C: Inj.Propofol 1mg/kg + Inj.Etomidate 0.2mg/kg bolus intravenous dose Give during induction of anaesthesia before endotracheal intubation Control Intervention1: Group A: Inj.Pro

Sponsors

Vidarshna V
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: � ASAI � Surgery under General Anaesthesia � Age 18-50 yrs � Male and Female patients

Exclusion criteria

Exclusion criteria: � Patient refusal � ASA II or higher � Emergency surgery requiring Rapid Sequence Induction and Intubation � Allergy to Propofol / Etomidate � Anticipated Difficult Airway

Design outcomes

Primary

MeasureTime frame
hemodynamic response to induction and endotracheal intubationTimepoint: Hemodynamic parameters (Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure) will be recorded at pre-induction(baseline),1, 2, and 3 minutes after induction and then at 0, 3, 5 and 10 minutes after endotracheal intubation.

Secondary

MeasureTime frame
Incidence of hypotensionTimepoint: Hemodynamic parameters (Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure) will be recorded at pre-induction(baseline),1, 2, and 3 minutes after induction and then at 0, 3, 5 and 10 minutes after endotracheal intubation.

Countries

India

Contacts

Public ContactVidarshna Viburajah

Sri Ramachandra Institute of Higher Education and Research

venkymail2014@gmail.com9944731220

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026