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Photo dynamic antimicrobial therapy for the treatment of pythium keratities

To observe the safety and efficacy of Photo dynamic therapy with Rose Bengal dye in patients with Pythium keratitis (Pilot Project).

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/11/029432
Enrollment
5
Registered
2020-11-27
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H160- Corneal ulcer

Interventions

Intervention1: Photo dynamic therapy with rose bengal dye for pythium keratities: 1.All subjects with proven (Pythium keratitis) on microbiology and following the inclusion criteria will be enrolled i

Sponsors

L V Prasad Eye Instituta
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. All cases with microbial keratitis with the infiltrate size between 2-8 with confirmed on smears and/or culture as Pythium by Microbiologist. 2. Ready to give consent 3. Consent for regular follow-up

Exclusion criteria

Exclusion criteria: 1. Mixed infection on smears or cultures 2. Not willing to come for regular follow-up or admission or giving consent 3. Posterior stromal involvement 4. Severe Pythium keratitis, with Limbal involvement 5. One eyed patient (other eye vision if less than 6/60 due to unmodifiable causes) 6. Allergic to Rose Bengal 7. Any associated collagen vascular disease

Design outcomes

Primary

MeasureTime frame
Outcome of Pythium keratitis in terms of resolution and adverse effects.Timepoint: 1 week, 2 week, 3 week, 1month, 3 month, 6 month

Secondary

MeasureTime frame
Number of patients undergone therapeutic Penetrating keratoplasty (TPK) for worsening of infection. Duration of response and complete resolution also measured.Timepoint: 1 week, 2 week, 3 week, 1 month, 3 month, 6 month

Countries

India

Contacts

Public ContactDrBhupesh Bagga

L V Prasad Eye Institute

bhupesh@lvpei.org04068102615

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026