Health Condition 1: P369- Bacterial sepsis of newborn, unspecified Health Condition 2: O601- Preterm labor with preterm delivery Health Condition 3: P073- Preterm [premature] newborn [other]
Conditions
Interventions
None listed
Sponsors
Manipal Academy of Higher Education
Eligibility
Inclusion criteria
Inclusion criteria: 1 All inborn preterm babies admitted to the Neonatal Intensive Care Unit. 2 Gestational age 3 Informed consent from the mother. 4 Neonate admitted to NICU for at least 28 days
Exclusion criteria
Exclusion criteria: 1 Neonate with Surgical/chromosomal abnormalities. 2.Neonates with necrotizing enterocolitis 3 Neonates undergoing Gastrointestinal surgeries. 4.Culture Negative Sepsis 5 No informed consent is given.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Patterned Progression of bacterial population of gut microbiota of preterm neonates and preterm neonates developing a neonatal infection. 2.Variability of gut microbial patterns due to mode of delivery, Influence of gestational age, antibiotic exposure and feeds in the preterm neonates with and without sepsis.Timepoint: 105 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.The gut microbial colonization pattern of preterm infants, in the first 28 days of life of infant to determine key insights into the onset of sepsis development, impact, and recovery. 2.Protective role of gut microbiota in modulating of neonatal sepsis. 3.Gut colonization pattern seen in neonates with resistant strain of bacteria. 4. Effect of antimicrobial therapy on gut microbiota dysbiosis. Timepoint: 105 weeks | — |
Countries
India
Contacts
Public ContactFaiza Iqbal
Manipal Academy of Higher Education
Outcome results
None listed