Health Condition 1: C040- Malignant neoplasm of anterior floor of mouth Health Condition 2: C060- Malignant neoplasm of cheek mucosa Health Condition 3: C039- Malignant neoplasm of gum, unspecified Health Condition 4: C009- Malignant neoplasm of lip, unspecified Health Condition 5: C031- Malignant neoplasm of lower gum Health Condition 6: C030- Malignant neoplasm of upper gum
Conditions
Interventions
None listed
Sponsors
AIIMS Rishikesh
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age â?? 18 to 70 years 2.Biopsy proven OSCC planned for upfront surgery 3.ECOG-PS 0-2
Exclusion criteria
Exclusion criteria: 1.History any prior cancer directed treatment 2.Any history of prior head or neck surgery. 3.Patient not willing to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.To identify the expression of Epithelial Mesenchymal Transition (EMT) markers in oral squamous cell carcinoma (OSCC).Timepoint: 18 months - patient accrual 36 months - data collection and analysis | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.To study EMT markers expression status in relation to OSCC stage. Timepoint: 18 months - patient accrual 36 months - data collection and analysis;To determine EMT markers expression role in predicting loco regional failure and survivalTimepoint: 18 months - patient accrual 36 months - data collection and analysis;To study correlation of EMT markers expression wit histopathological factors. Timepoint: 18 months - patient accrual 36 months - data collection and analysis;To study correlation of EMT markers expression with Tobacco abuse and HPV status Timepoint: 18 months - Patient Accrual 36 months - Data collection and analysis | — |
Countries
India
Contacts
Public ContactDr Dharma Ram Poonia
AIIMS
Outcome results
None listed