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A clinical study to compare high flow nasal oxygen and non invasive ventilation in patients with covid-19.

COMPARISON USE OF HIGH-FLOW NASAL CANNULA AND NON INVASIVE VENTILATION IN PATIENTS WITH COVID-19: A RANDOMIZED COMPARATIVE STUDY

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/11/029356
Enrollment
82
Registered
2020-11-25
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J09X- Influenza due to identified novelinfluenza A virus Health Condition 2: J09X- Influenza due to identified novelinfluenza A virus Health Condition 3: J22- Unspecified acute lower respiratory infection

Interventions

Intervention1: HFNC AND NIV: HIGH FLOW NASAL CANNULA AND NON INVASIVE VENTILATION IN PATIENTS WITH COVID-19 AND HEMODYNAMIC STABILITY Control Intervention1: HFNC AND NIV: TO COMPARE HFNC AND NIV AS FI

Sponsors

BLDEDU
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with COVID-19 rtPCR positive who requires HFNO and NIV as first line therapy. Patients aged between 20-60years and weighing 40-80kg.

Exclusion criteria

Exclusion criteria: Patients with pH Children Comorbidities like renal, cardiac and liver failure and morbid obesity.

Design outcomes

Primary

MeasureTime frame
Reduction in respiratory distress signs like decrease in respiratory rate and increase in saturation SpO2 90%. Improvement in hemodynamic stability such as Heart rate, respiratory rate and blood pressure. Timepoint: ON ADMISSION 6 HOURS 12 HOURS 24 HOURS 2ND DAY 4TH to 6TH DAY 1ST WEEK

Secondary

MeasureTime frame
Improvement in chest x-ray/High Resolution Computerised Tomography. ICU stay and outcome of HFNO and NIV. Incidence of failed HFNO and NIV who needs intubation.Timepoint: ON ADMISSION 6 HOURS 12 HOURS 24 HOURS 2ND DAY 4TH to 6TH DAY 1ST WEEK

Countries

India

Contacts

Public ContactDr Pratibha S D

BLDEU bijapur

pratibhakaradi@gmail.com9036110082

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026