None listed
Conditions
Interventions
Intervention1: Pistachio: Intervention arm participants will be provided approximately 60g of roasted pistachios daily as a part of everyday meal (30g/meal for 2 meals) adjusted for carbohydrate and f
Sponsors
American Pistachio Growers
Eligibility
Inclusion criteria
Inclusion criteria: Hypertension Pre-diabetes (Impaired fasting glucose: fasting capillary blood glucose >=110mg/dl and =140mg/dl but
Exclusion criteria
Exclusion criteria: Self-reported diabetes Current daily and weekly tobacco users History of allergy to nuts Patients on oral steroids, metformin, on hormonal replacement therapy History of bariatric surgery or have underwent any major surgery in last 6 months Use of nutritional supplements Bad dentures Patients with cancer, Patients on medications for psychiatric disorders, Active weight loss (more than 3 kg in the last month) • Pregnant/lactating women Presence of severe liver, kidney, thyroid, or other endocrine diseases Any condition that hinders compliance to the intervention. Possible eating disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in 1) fasting glucose, 2) 2hour post glucose load;Timepoint: 2 time points 1.Baseline-at the time of study commencement 2.End- at the end of 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in Insulin resistance measured by HOMA-IR Lipid profile changes in body weight and blood pressure Selected Pro-inflammatory and anti-inflammatory markers Cellular glucose uptake and mRNA gene expression studies Gut microbiome in a sub sample 24 hr glycemic response using flash glucose monitoring device.Timepoint: baseline-before commencement of study End of study-end of 3 months intervention | — |
Countries
India
Contacts
Public ContactSudha Vasudevan
MADRAS DIABETES RESEARCH FOUNDATION
Outcome results
None listed