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The protective effects of Gonadotropin releasing hormone agonist (GnRHa) in preventing the chemotherapy induced ovarian damage and transgenerational effects

Experimental approach to assess the protective effects of Gonadotropin releasing hormone agonist (GnRHa) in preventing the chemotherapy induced ovarian damage and transgenerational effects

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/11/029313
Enrollment
30
Registered
2020-11-24
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N971- Female infertility of tubal origin Health Condition 2: O94-O9A- Other obstetric conditions, not elsewhere classified

Interventions

Control Intervention1: Chemotherapeutic drugs (CHOP) and GnRHa (Gonadotropin releasing hormone agonist (GnRHa)): Granulosa cells isolated from 30 infertile patients will be used. The aspirates of foll

Sponsors

Indian Council of Medical Research ICMR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Infertile females with age more than 22 years and less than 35 years

Exclusion criteria

Exclusion criteria: Infertile females with age less than 22 years and more than 35 years

Design outcomes

Primary

MeasureTime frame
Response of Granulosa cells to chemotherapy and GnRHa (Gonadotropin releasing hormone agonist)Timepoint: The outcome will be assessed after 24 hour in-vitro culture—

Secondary

MeasureTime frame
Protective effect of GnRHa (Gonadotropin releasing hormone agonist) on Granulosa cells which was exposed to chemotherapyTimepoint: The protective effect will be assessed after 24 hour in-vitro exposure—

Countries

India

Contacts

Public ContactShubhashree Uppangala

Kasturba Medical College, Manipal, Manipal Academy of Higher Education,Manipal

shubha.u@manipal.edu9480009731

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026