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Effect of intramuscular versus sublingual atropine to decrease salivary secretion in oral surgeries

COMPARISON OF ANTISIALOGOGUE EFFECT OF ATROPINE VIA SUBLINGUAL AND INTRAMUSCULAR ROUTE AS PREMEDICATION â?? A CROSS SECTIONAL OBSERVATIONAL COMPARATIVE STUDYâ??

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/11/029242
Enrollment
100
Registered
2020-11-19
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Q670- Congenital facial asymmetry

Interventions

Control Intervention1: intramuscular and sublingual atropine: In this study we compare antisialagogue effect of atropine via 2 routes- intramuscular and sublingual as premedication by weighing dental

Sponsors

Dr Sneha
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Individuals aged 10-30 years, undergoing elective surgeries, under general anesthesia, Requiring antisialagogue premedication, American Society of Anesthesiologists (ASA) Physical Status 1 and 2

Exclusion criteria

Exclusion criteria: Presence of significant oral pathology like oral malignancies, recent history of aphthous ulcers,Patients with history of urinary retention, Patients with severe cardiorespiratory disorders,Patients with xerostomia and/or xeropthalmia, Any allergy to atropine, History of smoking, History of recent or current upper respiratory tract infection,Angle closure glaucoma, Severe hepatic and renal diseases, Patient on any medications interfering with salivation

Design outcomes

Primary

MeasureTime frame
To compare the quantity of saliva produced 45 minutes after introducing atropine via sublingual and intramuscular routes in gramsTimepoint: 45 minutes

Secondary

MeasureTime frame
1.To assess and compare dryness caused by atropine administered via sublingual and intramuscular routes 2.To estimate the changes in cardiovascular system by atropine via sublingual and IM routes by non-invasive blood pressure (systolic BP, diastolic BP, mean arterial pressure), heart rate, temperature Timepoint: HR - beats/minute BP- mm Hg temperature- degree celcius

Countries

India

Contacts

Public ContactDr Sneha S

KS hegde medical academy

sripadamehandale@nitte.edu.in8310618456

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026