FindTrial
Sign In

Role of Heparin inhalation in reducing the duration the patient is breathing with the help of a ventilator

Role of Heparin Nebulization in Reducing Time of Mechanical ventilation in patients with SARS-CoV-2

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/11/029175
Enrollment
58
Registered
2020-11-17
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere Health Condition 2: J22- Unspecified acute lower respiratory infection

Interventions

Intervention1: Heparin Nebulization plus Standard care: Each participant will be assigned to nebulised heparin sodium 25,000 Units in 5 mL or an equivalent unfractionated heparin, the frequency being

Sponsors

AIIMS Patna
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Confirmed COVID-19, Endotracheal tube in place, Intubated the day before or same day, PaO2 to FIO2 ratio less than or equal to 300 while intubated, Acute opacities not fully explained by effusions, lobar/lung collapse and nodules, affecting at least one lung quadrant on chest X-ray or CT, Currently in the ICU or scheduled for transfer to the ICU.

Exclusion criteria

Exclusion criteria: Enrolled in another clinical trial that is unapproved for co-enrolment, Heparin allergy or HIT, APTT > 120 seconds and this is not due to anticoagulant therapy, Platelet count

Design outcomes

Primary

MeasureTime frame
The primary outcome is the time to separation from mechanical ventilation (duration of mechanical ventilation) upto day 28Timepoint: The primary outcome is the time to separation from mechanical ventilation (duration of mechanical ventilation) upto day 28—

Secondary

MeasureTime frame
ï?? Change in oxygenation index, driving pressure and ventilatory ratio at day 2 ï?? Change in white cell count, platelet count, C-reactive protein, D-dimer and INR to day 10 ï?? Number tracheotomised to day 28 ï?? Time to separation from the ICU to day 28, among survivors ï?? Survival to day 28; Survival to day 60; and Survival to hospital discharge, censored at day60 ï?? Number residing at home or in a community setting at day 60, among survivors Timepoint: the time to separation from mechanical ventilation (duration of mechanical ventilation) upto day 10 or 28 or 60 days as applicable.—

Countries

India

Contacts

Public ContactShagufta Naaz

AIIMS Patna

drshaguftanaaz@gmail.com07765937919

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026