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A First of a study to assess the efficacy of increased oxygen supplementation in keratoconus patients undergoing accelerated corneal collagen cross linking

A Pilot Study to Compare Accelerated Corneal Cross Linking Under Normal and Increased Oxygen Tension in Keratoconus

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/11/029122
Enrollment
20
Registered
2020-11-13
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H186- Keratoconus

Interventions

Intervention1: Increased oxygen tension(90%) supplied using corneal goggles: With epithelium debrided, the first group will undergo accelerated corneal collagen cross links(Riboflavin 0.1% for 20min,

Sponsors

All India Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Progressive keratoconus 2. Age >16 years 3. Willingness to participate and follow up. 4. Corneal thickness >400 micrometres

Exclusion criteria

Exclusion criteria: 1. Age 2. h/o past ocular surgery 3. Associated ocular co morbidity 4. Corneal scarring 5. One eyed patient 6. Unwilling to participate and follow up. 7. Corneal thickness <400micrometers.

Design outcomes

Primary

MeasureTime frame
1. Percentage of patients that achieve stabilisation of keratometry values. 2. Reduction in refractive and keratometric astigmatismTimepoint: Pre-Acceletrated collagen cross linking, 1 week, 1 month, 3 month, 6month—

Secondary

MeasureTime frame
Change in biomechanical strengthTimepoint: Pre-Acceletrated collagen cross linking, 1 week, 1 month, 3 month, 6month—

Countries

India

Contacts

Public ContactMohammed Sabir

All India Institute of Medical Sciences

sinharaj1@gmail.com9868937900

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026