Health Condition 1: N460- Azoospermia Health Condition 2: N469- Male infertility, unspecified Health Condition 3: N461- Oligospermia Health Condition 4: N468- Other male infertility
Conditions
Interventions
None listed
Sponsors
AIIMS Mangalagiri
Eligibility
Inclusion criteria
Inclusion criteria: Cases: All couples with male factor infertility as diagnosed on semen analysis will be included as cases Controls: All male partners of infertile couples with normal semen analysis will be enrolled as controls. The male partners in both cases and controls will be selected from 20-50 years of age group.
Exclusion criteria
Exclusion criteria: Male partners with acute infection, fever, subjects currently on some infertility treatment or drugs, subjects with chronic diseases like diabetes mellitus, renal or liver diseases, prostate or any other malignancy, subjects with aspermia, cryptorchidism, bilateral absence of vasa deferens (CABVD), testicular dysgenesis syndrome or any other congenital abnormalities, subjects with Hypospadias or Retrograde ejaculation will be excluded from cases and controls.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the role of seminal plasma TEX 101, PSA antibodies and MDA levels as biomarkers of male infertility.Timepoint: The values of seminal plasma TEX 101, PSA antibodies and MDA levels as biomarkers of male infertility will be assessed after 1 year. | — |
Secondary
| Measure | Time frame |
|---|---|
| To develop effective non - invasive seminal plasma biomarkers for detection of causes of male infertility. Timepoint: Comparison of TEX 101, Prostate specific antigen antibodies and MDA between cases and controls will be done after 10-12 months | — |
Countries
India
Contacts
Public ContactNaina Kumar
All India Institute of Medical Sciences, Mangalagiri
Outcome results
None listed