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Curcumin for the Management of Periodontitis and Early Rheumatoid Arthritis: Killing Two Birds with One Stone

â??THE EFFECT OF NUTRITIONAL SUPPLEMENTATION WITH CURCUMIN ON ALKALINE PHOSPHATASE LEVELS IN GINGIVAL CREVICULAR FLUID OF CHRONIC PERIODONTITIS AND RHEUMATOID ARTHRITIS PATIENTS: A RANDOMIZED CONTROLLED TRIAL.â??

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/11/029047
Enrollment
60
Registered
2020-11-11
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: scaling and root planing: scaling and root planing and review after 6 weeks Control Intervention1: curcummin and gelatin capsule: Tab.curcummin 500mg morning and night after food for 6

Sponsors

Dr Manjunath S M
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients suffering from chronic periodontitis. 2) Probing pocket depth >=5mm. 3) Clinical attachment loss >=3mm. 4) Number of remaining teeth >=20 excluding third molars. 5) Patients suffering from chronic periodontitis and early stages of rheumatoid arthritis. 6) With elevated ESR( >30mm/hr.), 7) C- Reactive Protein( >10.0mg/l), 8) Rheumatoid factor ( >20U/ml), 9) Anticyclic citrullinate peptide ( >20U/ml). 10) Rheumatoid arthritis patients, who are not on disease-modifying anti-rheumatic drugs, or DMARDs 11) Patients between age group 20-65 years. 12) Patients with no history of allergy to drugs used or prescribed in this study

Exclusion criteria

Exclusion criteria: 1) Rheumatoid arthritis patients, who are on disease-modifying anti-rheumatic drugs, or DMARDs 2) Pregnant and lactating females. 3) Patients who have undergone periodontal treatment within a period of 6 months. 4) Patients with plaque index > 1 and who donâ??t follow oral hygiene instructions after phase I therapy. 5) Patients on steroid therapy and oral contraceptives. 6) History of tobacco chewing and current or former smoker. 7) Patients who did not accept terms and conditions of the study.

Design outcomes

Primary

MeasureTime frame
1. To study the effect of nutritional supplementation with curcumin on Alkaline Phosphatase levels in gingival crevicular fluid of patients with chronic periodontitis. 2. To Compare and Evaluate the effect of nutritional supplementation with curcumin on Alkaline Phosphatase levels in gingival crevicular fluid of patients with chronic periodontitis and rheumatoid arthritis patients. 3. To study the use of curcumin as an adjunct in the treatment of periodontal diseases Timepoint: at base line and 6 weeks—

Secondary

MeasureTime frame
not applicableTimepoint: not applicable—

Countries

India

Contacts

Public ContactDr Manjunath S M

Rajarajeswari dental college

kripalkrishna@yahoo.com9448938893

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026