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Comparison between misoprostol pushed rectally and given below tongue before cesarean section to control blood loss during and after the surgery.

Comparison between rectal versus sublingual misoprostol before cesarean sections to control intra- and postoperative blood loss: a double blind, randomized controlled study.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/11/029043
Enrollment
188
Registered
2020-11-11
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O721- Other immediate postpartum hemorrhage Health Condition 2: O720- Third-stage hemorrhage

Interventions

Intervention1: Rectal misoprostol: Patients belonging to group 1 will be given 2 tablets of 200 microgram misoprostol per rectally just before giving skin incision in caesarean section. Intervention2

Sponsors

IPGMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Term pregnancy, singleton pregnancy, scheduled for elective lower segment caesarean section under spinal anaesthesia.

Exclusion criteria

Exclusion criteria: Hb% < 10 gm%, multifetal gestation, antepartum haemorrhage, polyhydramnios, two or more previous caesarean section, hypertension in pregnancy, history of heart, liver and renal disorder, active thromboembolic disease or previous history of thromboembolism, hypersensitivity to prostaglandins.

Design outcomes

Primary

MeasureTime frame
Blood loss within 2hours of birth: The suction bottle is changed following delivery of baby and blood loss is measured from the amount of blood collected in suction bottle plus weight of wet mops and drapings- weight of dry mops and drapings (assuming density 1gm /cc)plus blood loss every 15 minutes within 2hours after delivery from the weight of wet sanitary pads - weight of dry sanitary pads (assuming density 1gm /cc) Timepoint: 2 hours

Secondary

MeasureTime frame
1.Blood loss within 24hrs of birth at every moment the women discard sanitary pads (weight of wet sanitary pad minus weight of dry sanitary pad),2. Hemoglobulin and hematocrit before delivery and 24 hours after delivery, 3.Maternal death, maternal critical care unit admission, major surgical or invasive procedure, blood transfusion.Timepoint: 24 hours

Countries

India

Contacts

Public ContactDr Anubrata Pharikal

IPGMER

khooshee@hotmail.com9830173132

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026