Health Condition 1: - Health Condition 2: 3- Administration
Conditions
Interventions
Intervention1: ketamine -dexmedethomidine: Ketamine (0.5mg/kg)+dexmedetomidine(1mcg/kg) given through intravenous over 10mins with nebulisation with normal saline over 10mins in one group and same dru
Sponsors
Chaitra
Eligibility
Inclusion criteria
Inclusion criteria: 1. Pateints giving written informed consent will be taken. 2. Aged between 18-60years of both sex with ASA physical status I and II. 3. Patients with anticipated difficult airway undergoing elective surgical procedures.
Exclusion criteria
Exclusion criteria: Any type of A-V block on electrocardiogram (ECG), heart failure, coronary heart disaese. liver cirrhosis, thrombocytopenia and coagulopathies severe bradycardia current psychiatric disorder, history of seizures any respiratory disorders history of epistaxis, nasal pathology known drug allergy to the study drugs ASA III and ASA IV pregnant female Emergency procedures Patient refusal
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time required for intubation between group receiving dexmedetomidine+ketamine through intravenous route and group receiving dexmedetomidine+ketamine through nebulisation. Timepoint: Time required for intubation is calculated when first reading obtained by capnograph after entotracheal intubation. That is after 10mins of baseline till first capnograph reading. | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse eventsTimepoint: postoperative period;cough severityTimepoint: while passing the fibreoptic bronchoscope;ease of intubationTimepoint: while passing the endotracheal tube through vocal cords;hemodynamic changes (HR,SBP,DBP,MAP,ECG,SPO2)Timepoint: baseline,2mins,4mins,6mins,8mins,10mins,fibreoptic through nostril,ETT through nasopharynx,ETT through glottis,5mins after intubation and 10mins after intubation;patient toleranceTimepoint: whicle performing the procedure;recall of events and discomfort during procedureTimepoint: postoperative period;the sedation scoreTimepoint: at the end of trial drug administration | — |
Countries
India
Contacts
Public ContactDr Tanmay Tiwari
King George Medical University
Outcome results
None listed