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Effect of Oral Antibiotics and Potent Anti-acne drug on the Levels of Blood markers in Acne Patients

Effect of Oral Doxycycline, Azithromycin and Isotretinoin on Serum Red Cell Distribution Width, Platelet Lymphocyte Ratio And Interleukin-17 levels in Acne vulgaris: A single blinded Randomised Interventional Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/11/028992
Enrollment
120
Registered
2020-11-09
Start date
Unknown
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L700- Acne vulgaris

Interventions

Intervention1: oral azithromycin: Tab. Azithromycin 500 mg oral thrice weekly till 12 weeks or till remission whichever is earlier Intervention2: oral doxycycline: Cap. Doxycycline 100 mg oral daily t

Sponsors

All India Institute of Medical Sciences Jodhpur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with moderate and severe acne vulgaris (GAGS: 19-38) Treatment wash off period for oral macrolides, tetracyclines, isotretinoin > 1 month

Exclusion criteria

Exclusion criteria: Suspected/ Clinically confirmed hormonal acne Nodulocystic acne and other severe variants like acne fulminans Patients with other inflammatory dermatosis like psoriasis Moderate anaemia ( Any known case of haematological disorder Cigarette smoking Pregnancy and Lactation Uncontrolled systemic illnesses such as diabetes mellitus, hypertension, coronary artery disease, thyroid dysfunction, infection

Design outcomes

Primary

MeasureTime frame
To compare the pre-treatment and post-treatment serum levels of RDW, PLR and IL-17 in patients with moderate and severe grade acne vulgaris. Timepoint: At baseline and then at every 4 weeks till 12 weeks or till remission whichever is earlier—

Secondary

MeasureTime frame
To assess the correlation between the change in serum levels of RDW, PLR and IL 17 after therapy Timepoint: At baseline and at remission;To compare the clinical effects of doxycycline, azithromycin and isotretinoin in patients with moderate and severe grade acne vulgaris. Timepoint: At baseline and at remission;To compare the side effects doxycycline, azithromycin and isotretinoin in each group Timepoint: At baseline and at remission—

Countries

India

Contacts

Public ContactAkriti Agrawal

AIIMS Jodhpur

dr.abhishekbhardwaj@gmail.com7063956224

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026