Health Condition 1: H160- Corneal ulcer
Conditions
Interventions
Intervention1: Corneal Collagen cross linking using Rose Bengal Dye and Green light: Single treatment of Corneal Collagen cross linking using Rose Bengal Dye and Green light, along with the Standard t
Sponsors
The National Eye Institute at the National Institute of Health
Eligibility
Inclusion criteria
Inclusion criteria: 1) Presence of smear or culture positive fungal or acanthamoeba ulcer OR 2) Presence of smear and culture negative ulcer 3) Visual Acuity worse than 20/40 4) Willingness to participate
Exclusion criteria
Exclusion criteria: 1) Evidence of herpetic keratitis 2) Impending of frank corneal perforation 3) History of recent intraocular surgery 4) Fellow eye visual acuity 5) Inability to understand and participate with the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Best corrected Visual AcuityTimepoint: 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Best corrected Visual Acuity at 12 months 2. Adverse events needing TPK 3. Microbiological cure on day-2 repeat smear and culture 4. Infiltrate/scar measurement 5. Change in Visual Function Questionnaire from baseline to 6 months 6. Pain scale at baseline at day 1 and 3Timepoint: 12 months | — |
Countries
India, United States of America
Contacts
Public ContactDr N Venkatesh Prajna
Aravind Eye Hospital and Postgraduate Institute of Ophthalmology
Outcome results
None listed