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To know the difference between using oxygen only and oxygen plus nitrous oxide when inducing patients for general anaesthesia in terms of dose and time of propofol.

A single blinded randomized study to compare effect of mixture of nitrous oxide and oxygen inhalation with oxygen alone in terms of induction dose of propofol and induction time, oxygen saturation and hemodynamic responses to laryngoscopy.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/11/028928
Enrollment
60
Registered
2020-11-05
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group PN: Receiving the mixture of nitrous oxide and oxygen inhalation with propofol as induction agent Control Intervention1: Group PO: Receiving only 100% oxygen inhalation and propof

Sponsors

Dr S N Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.All patients with ASA status I and II of either sex 2.Age between 20 to 60 years 3.Body mass index between 20-35kg/m2 4.Oropharyngeal anatomy of mallampati class I and II presenting for elective surgery under general anaesthesia needing endotracheal intubation.

Exclusion criteria

Exclusion criteria: 1.refuse to participate 2.pregnant females 3.patient with difficult airway i.e cormack and Lehane grade of laryngeal view III and IV 4.morbid obesity 5.Allergy to the drug used in the study 6.pts with COPD bronchial asthma,Interstitial lung disease,and uncontrolled hypertension 7.patients with relative contraindications for use of nitrous oxide such as intestinal obstruction,middle ear surgeries, pneumothorax,air embolism 8.Patients undregoing cardiac surgery

Design outcomes

Primary

MeasureTime frame
To compare the effect of mixture of nitrous oxide and oxygen inhalation with oxygen alone in terms of induction dose of propofol during general anaesthesiaTimepoint: Till induction time—

Secondary

MeasureTime frame
To compare the effect of mixture of nitrous oxide and oxygen inhalation with oxygen alone in terms of induction time ,oxygen saturation and hemodynamic responses to laryngoscopy during general anaesthesiaTimepoint: Till 10 min after intubation—

Countries

India

Contacts

Public ContactDr R K Solanki

Dr S N Medical college Jodhpur

rajendrakumar55550@gmail.com9414131931

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026