Health Condition 1: G40- Epilepsy and recurrent seizures
Conditions
Interventions
Intervention1: Escitalopram: Escitalopram 5mg/day for 1 week then 10mg/day for 3 weeks followed by 20mg/day for 4 weeks in non responders (responders will continue 10mg/day for next 4 weeks)
Contro
Sponsors
Dr Manjari Tripathi
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age >18years 2. Patients with generalized and focal epilepsy on antiseizure medications(ASM) 3. Patients eligible using 21 item Hamiltonââ?¬•s depression rating scale.
Exclusion criteria
Exclusion criteria: 1. Patients who scored severe and very severe depression score on Hamiltonââ?¬•s depression rating scale 2. Psychogenic non-epileptic seizures 3. Any women who want to conceive or pregnant women 4. Unable to give consent 5. Patients having intellectual disability. 6. Any terminal illness such that the patient would not be expected to survive long. 7. Patient with significant non- neurological co-morbidities like chronic cardiac, renal and other systemic diseases that can also causes depression 8. Patients with hepatic disease ,renal disease and with prolonged QTc interval. 9. Any condition that, in the judgement of the investigator could impose hazards to the patient if study therapy is initiated or affect the participation of the patient in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| âÅ?â? To study the difference in efficacy and adverse event profile of antidepressants in mild to moderate depression in PWE at 8 weeks follow up.Timepoint: 8 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| âÅ?â? To study if adjunctive therapy with antidepressants along with standard antiseizure medications has any effect on seizure frequency in PWE at 8 weeks follow up. âÅ?â? To assess quality of life, adherence with antidepressants in PWE at 8 weeks follow up Timepoint: 8 weeks | — |
Countries
India
Contacts
Public ContactPrashant bhatele
Affiliation All India Institute of Medical Sciences, New Delhi
Outcome results
None listed