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Identification of risk factors for oral precancer and cancerous lesions.

Identification of risk factors and its correlation with somatic mutational signatures in oral pre cancer and cancers for risk prediction and early detection.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/11/028878
Enrollment
1200
Registered
2020-11-04
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C00-C14- Malignant neoplasms of lip, oral cavity and pharynx

Interventions

Control Intervention1: Exome sequencing and Whole genome sequencing: Identify early detection biomarkers for oral pre cancer and oral cancer. Identify mutational signature associated with different e

Sponsors

Center for Cancer Epidemiology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: oral precancer and oral cancer lesions

Exclusion criteria

Exclusion criteria: History of cancer. Prior history of precancer/cancer directed treatment

Design outcomes

Primary

MeasureTime frame
Conduct a whole exome sequencing to characterize the landscape of somatic mutations in oral pre-cancers and cancers.Timepoint: 2 Years—

Secondary

MeasureTime frame
1)Conduct a whole genome sequencing on tumour-blood pair to identify mutation signature attributed to exposures. 2)Conduct a whole genome sequencing on oral pre-cancer -blood pair to identify mutation signature attributed to exposures. 3)To investigate the feasibility and validity of the measurement of driver somatic mutations in less-invasively collected samples, such as oral cytology samples, saliva, and oral rinses. Timepoint: 2 years—

Countries

India

Contacts

Public ContactNaveen Khargekar

Homi Bhabha Cancer Hospital

naveenkhargekar@gmail.com9867191421

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026