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Effects of Anaesthesia On Immune Suppression, Inflammation AND Metastasis Of Breast Cancer.

Effect of anaesthetic agents on immuno-inflammatory response of breast cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/11/028826
Enrollment
40
Registered
2020-11-03
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C50- Malignant neoplasm of breast

Interventions

Intervention1: Propofol TIVA: Maintenance of anaesthesia will be done using target controlled infusion of propofol, using Schnieder model for effect site concentration, along with endotracheal intubat

Sponsors

Chittaranjan National Cancer Institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Newly diagnosed breast cancer (Unilateral) confirmed with histopathological diagnosis. 2. ASA I (Normal healthy patient) & ASA II (Patient with mild systemic disease) 3. T1 N0, T2N0, T3N0, T1N1, T2N1, T3N1 Mx 4. Both male & female 6. Duration of surgery

Exclusion criteria

Exclusion criteria: 1. Patient having any kind of anticancer treatment 2. Active bleeding 3. Recent history of massive blood transfusion 4. Pregnant & Lactating woman

Design outcomes

Primary

MeasureTime frame
Frequency and activity of NK cellsTimepoint: 1. Intra-operatively after 1 hour of incision. 2. 48 hours post-operatively—

Secondary

MeasureTime frame
1. Frequency of T-lymphocytes, B-lumphocytes. 2. Expression of TNF-alpha, IL-6, IL- 8, IL-10, MMP-2, MMP-9.Timepoint: 1. Intra-operatively after 1 hour of incision. 2. 48 hours post-operatively—

Countries

India

Contacts

Public ContactDr Deepa Chakrabarti

Chittaranjan National Cancer Institute

deepajayanta@gmail.com9830068348

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026