Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Dexmedetomidine and scalp block: Dexmedetomidine bolus @1mcg/kg over 10 mins before induction followed by 0.2-0.7 mcg/kg/hr. + Scalp block with ropivacaine [0.25%] after induction of an
Sponsors
AIIMS New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1. Written informed consent 2. American Society of Anesthesiologists class I&II 3. Age of >65 years 4. Either gender 5. Supratentorial brain tumor with tumor diameter of 6. Full Glasgow coma score (E4V5M6) 7. Estimated operative time of
Exclusion criteria
Exclusion criteria: 1. Non consenting patient 2. Any history of previous brain surgery 3. Current or past history of any cardiac disease or medication 4. Any history of lung disease, liver or kidney dysfunction 5. Patients who had sensitivity to opioids, dexmedetomidine, ropivacaine 6. Body mass index of > 35 kg/m2 7. Preoperative cognitive dysfunction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Time to emergence 2.Postoperative immediate painTimepoint: 1.From discontinuation of anesthetics to eye opening on command in minutes 2. 10 minutes after extubation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Extubation timeTimepoint: 1. From discontinuation of anesthetics to tracheal extubation in minutes;10. Intraoperative hemodynamic disturbances [hypotension, bradycardia] Timepoint: intraoperative period;11. Intraoperative fentanyl consumption Timepoint: End of surgery;2. Postoperative deliriumTimepoint: 2. Assessed using CAM-ICU 60 minutes after extubation;3. Postoperative early cognitive dysfunctionTimepoint: Assessed using MMSE 60 minutes after extubation];4. Postoperative side effects: nausea,vomiting, shivering, hemodynamic instability, respiratory depressionTimepoint: Postoperative period[24 hrs];5. Other respiratory parameters (any subclinical respiratory depression): Ph, PaO2, PaCo2, Hco3, Lact, Sao2, HbTimepoint: Postoperative period [24 hrs];6. Time for first rescue analgesic:Timepoint: Postoperative period [24 hrs];7. Length of ICU stay Timepoint: .;8. Length of Hospital stay Timepoint: .;9. Intraoperative brain relaxation [Cerebral relaxation score] Timepoint: intraoperative period | — |
Countries
India
Contacts
Public ContactIndu Kapoor
AIIMS, NEW DELHI
Outcome results
None listed