A study to compare a combination of medications(Lignocaine, Magnesium and ketamine) versus Lignocaine given through blood in Laparoscopic Hernia surgery(Laparoscopic Intra peritoneal Onlay mesh Repair) for pain relief

Comparison of postoperative analgesia in laparoscopic IPOM between a continuous intravenous infusion of combined Lidocaine, magnesium and ketamine and continuous intravenous infusion of Lidocaine â?? A double blinded randomized control trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/10/028760

Enrollment

Registered

2020-10-29

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K458- Other specified abdominal hernia without obstruction or gangrene

Interventions

Intervention1: Continuous infusion of magnesium,Ketamine and lignocaine: Lignocaine 1mg/kg/hr Magnesium 10mg/kg/hr Ketamine 0.1mg/kg/hr Till the skin closure Control Intervention1: Lignocaine infusion

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 18-70 yrs. 2.ASA 1&2

Exclusion criteria

Exclusion criteria: 1. Patient refusal 2. ASA 3 and more 3. Seizure disorder on medication 4. Liver dysfunction (elevated transaminases) 5. Chronic renal disease (Creatinine >1.4mg/dl) 6. Opioid dependence 7. Cardiac dysfunction (Ejection fraction 8. Uncontrolled Hypertension 9. Calcium channel blocker 10. Morbid obesity (BMI >35) 11. Allergy to any of the drugs

Design outcomes

Primary

Measure	Time frame
To compare the postoperative pain for 48 hours after post-operative period using VASTimepoint: To compare the postoperative pain at 2,4,6,8,12,18,24,30,36,42,48 hours of post-operative period using VAS	—

Secondary

Measure	Time frame
To compare the total opioid requirement between both groups 2.To evaluate the incidence of PONV 3.To compare quality of recovery using QoR15 Timepoint: 6 HR INTERVAL	—

Countries

India

Contacts

Public ContactProf Dr Tony Thomson Chandy

Christian Medical College

tonythomson@gmail.com9500242412

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026