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To Find out the link between a Blood Protien which function as antibodies (Immunoglobulin-G) to a bacteria (Porphyromonas gingivalis) and Early chronic Kidney Disease Stages (1-3) in Diabetic and Non Diabetic group of Patients with advanced Gum Disease

To Study the Association Between Serum Immunoglobulin -G To Porphyromonas gingivalis and Early Chronic Kidney Disease Stages (1-3) In Diabetic And Non Diabetic Patients With Periodontitis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/10/028747
Enrollment
80
Registered
2020-10-29
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E082- Diabetes mellitus due to underlying condition with kidney complications

Interventions

None listed

Sponsors

JSSAHER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Individuals within the age group of 40-68 years both male and female will be included in study 2. Periodontitis Patients with Pocket depth 4mm or more than 4mm 3. Diabetic Patients with Diabetes of more than 3 years of duration and Glycated hemoglobin more than 6.5 %. 4. Patients with GFR 30-59 mlmin or more than that will be included in the study (CKD stage1,2 and 3)

Exclusion criteria

Exclusion criteria: 1. Patients with GFR 15-29 ml/min or less than that (CKD stage 4 and Stage 5) 2. Patients who undergone hemodialysis, peritoneal dialysis or kidney transplantation 3. Patients with cardiovascular disease like congestive heart failure, myocardial infarction and cancer 4. Patient under immunosuppressive drugs 5. Patients undergoing or undergone periodontal therapy in the past 3 months. 6. Patient with history of anemia 7. Pregnant and gestational diabetes 8. Patients with Hypertension and Smokers 9. Patients with systemic Diseases that could acutely affect the GFR (rapid progressive glomerulo-nephritis, active glomerular diseases) and Renal stones

Design outcomes

Primary

MeasureTime frame
1. The markers of chronic kidney disease (albumin and creatinine) in diabetic and non diabetic individuals with periodontitis. 2. IgG titers to Porphyromonas gingivalis in diabetic and non-diabetic individuals with periodontitis. 3 comparing the IgG titers to Porphyromonas gingivalis with the markers of Chronic Kidney Disease in diabetic and non-diabetic individuals with periodontitis Timepoint: Baseline , No follow UP—

Secondary

MeasureTime frame
4. To check the Periodontal Pocket Depth and Glycated Hemoglobin towards the progression of Chronic Kidney Disease (CKD) in Diabetic PatientsTimepoint: Baseline , No follow Up—

Countries

India

Contacts

Public ContactMinusha grace S

JSS dental College and Hospital

sheelagujjari@gmail.com9448836777

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026