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A study to compare a monitoring tool value (Surgical Plethysmographic Index) before waking up the patient from general anaesthesia to predict pain after surgery while using two medications (isoflurane and sevoflurane) for providing the general anesthesia during surgery.

A prospective observational study to compare the Surgical Plethysmographic Index (SPI) value prior to arousal to predict acute postoperative pain between isoflurane and sevoflurane based general anaesthesia.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/10/028737
Enrollment
100
Registered
2020-10-29
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring Health Condition 2: R52- Pain, unspecified

Interventions

Control Intervention1: Sevoflurane: Flourinated methyl isopropyl ether used to provide general anesthesia by inhalation route Control Intervention2: Isoflurane: Halogenated methyl ethyl ether used to

Sponsors

Purva Makhija
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients receiving general anaesthesia with isoflurane and sevoflurane as the inhalational agent

Exclusion criteria

Exclusion criteria: 1.Patients on beta-blockers, calcium channel blockers, any anti-hypertensive medications 2.Patients diagnosed with peripheral artery disease, hypertension, cardiovascular disease 3.known conditions affecting peripheral perfusion like coarctation of aorta etc 4. History of long standing diabetes mellitus 5. Vaso-active drug administration 10 minutes prior to the reading of surgical pleth index(SPI) before arousal 6. Patients with pacemakers and cardiac arryhthmias 7. Patients receiving analgesia via epidural catheter and nerve blocks

Design outcomes

Primary

MeasureTime frame
To compare whether the SPI value obtained at the end of surgery during general anesthesia using equi-MAC isoflurane or sevoflurane corresponds to similar NRS score postoperativelyTimepoint: Last 10 minutes of sugery,SPI value will be recorded At 5 minutes and 15 minutes post operatively, NRS will be recorded—

Secondary

MeasureTime frame
To evaluate the varying response of the observing anesthetist to the changes in SPI value by increasing/decreasing the amount of volatile anesthetic agent to increase/decrease the depth of anesthesia or administering opioid or non-opioid analgesic, or not interveningTimepoint: Evaluated during the entire duration of surgery—

Countries

India

Contacts

Public ContactDr Krishna HM

Kasturba Medical College, Manipal

hmkrishna20032002@yahoo.com9845425862

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026