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This is a study to compare the effects of three drugs which are intravenous Dexmedetomidine, Magnesium Sulphate and Esmolol in reducing the stress response during laryngoscopy and endotracheal intubation during general Anaesthesia

Comparison of intravenous Dexmedetomidine, Magnesium Sulphate and Esmolol on the attenuation of pressor stress response to laryngoscopy and endotracheal intubation.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/10/028693
Enrollment
45
Registered
2020-10-28
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: DRUG: ADMINISTRATION OF DEXMEDETOMIDINE, MAGNESIUM SULPHATE OR ESMOLOL BEFORE LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION. Intervention2: Administration of intravenous dexmedetomidine, mag

Sponsors

MAULANA AZAD MEDICAL COLLEGE
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.PATIENTS UNDERGOING ELECTIVE SURGERY UNDER GENERAL ANAESTHESIA. 2. AMERICAN SOCIETY OF ANAESTHESIOLOGISTS PHYSICAL STATUS I AND II PATIENTS.

Exclusion criteria

Exclusion criteria: 1. PATIENTS WITH KNOWN SENSITIVITY TO ANY STUDY DRUG. 2. PREGNANT FEMALES. 3. PATIENTS WITH CHRONIC HYPERTENSION AND DIABETES MELLITUS. 4. PATIENTS WITH HISTORY OF CARDIAC OR RESPIRATORY ILLNESS. 5. PATIENTS WITH ANTICIPATED DIFFICULT AIRWAY. 6. PATIENTS WITH IMPAIRED KIDNEY OR LIVER FUNCTION.

Design outcomes

Primary

MeasureTime frame
COMPARISON OF INTRAVENOUS DEXMEDETOMIDINE, MAGNESIUM SULPHATE AND ESMOLOL FOR ATTENUATION OF PRESSOR RESPONSE(HEART RATE AND BLOOD PRESSURE) TO DIRECT LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION.Timepoint: AT THE TIME OF ARRIVAL IN THE OPERATING ROOM, AND AT 1 MINUTE, 3 MINUTE, 5 MINUTE AND 10 MINUTE AFTER INTUBATION.—

Secondary

MeasureTime frame
COMPARISON OF INTRAVENOUS DEXMEDETOMIDINE, MAGNESIUM SULPHATE AND ESMOLOL FOR ATTENUATION OF METABOLIC STRESS RESPONSE(SERUM CORTISOL AND BLOOD GLUCOSE) TO DIRECT LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION.Timepoint: AT THE TIME OF ARRIVAL IN THE OPERATING ROOM AND 10 MINUTES AFTER INTUBATION.—

Countries

India

Contacts

Public ContactKAJOL AGGARWAL

MAULANA AZAD MEDICAL COLLEGE AND ASSOCIATED HOSPITALS

lalitachaudhary055@gmail.com9968299710

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026