Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Melatonin: 6 mg, oral, 60 minutes before induction of anesthesia
Intervention2: Clonidine: 0.2 mg, oral, 60 minutes before induction of anesthesia
Control Intervention1: Placebo: sugar
Sponsors
Paras Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients in age group of 20 to 60 years 2. ASA grade I or II 3. Elective surgery under general endotracheal anaesthesia 4. Multivariate risk index (MVRI) score less than 4
Exclusion criteria
Exclusion criteria: 1. Patients less than 20 and more than 60 years of age 2. ASA grade III or IV 3. Anticipated difficult intubation 4. Body Mass Index (BMI) greater than 30 kilograms per meter square 5. Modified Mallampatti grade III or IV 6. MVRI equal to or more than 4 7. Emergency surgeries 8. Patient’s refusal to participate in the study 9. Patient receiving treatment with either of the study drug that is melatonin or clonidine; or having any known allergy to these drugs. 10. Patients receiving treatment for any cardiac illness, pregnancy, renal disease, liver disease, morbid obesity, bleeding disorder. 11. Patients on anti-hypertensives, oral hypoglycemics, anti-depressants, anti-convulsants, anti-psychotics, and birth control pills. 12. Pregnant and lactating females.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| heart rate, systolic blood pressure, diastolic blood pressure, mean blood pressure, rate pressure product, and oxygen saturation.Timepoint: before drug administration, after 30 minutes of drug administration, before induction, immediately after intubation (0 minute), and 1,2,3,5,10 minutes following endotracheal intubation. | — |
Secondary
| Measure | Time frame |
|---|---|
| propofol doseTimepoint: at the time of induction rescue doses during surgery;volume of inhalational anesthetic agentTimepoint: Every 15 minutes during surgery | — |
Countries
India
Contacts
Public ContactDr Apra Singh Rai
Paras Hospital
Outcome results
None listed