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To study the effect of variations in different genes of vascular system in Pre-eclampsia females

Evaluation of genetic susceptibility of Vascular endothelial dysfunction in Pregnant North Indian Females with Pre-eclampsia

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/10/028676
Enrollment
150
Registered
2020-10-27
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O149- Unspecified pre-eclampsia

Interventions

None listed

Sponsors

GNCT Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 75 women with PE and 75 healthy pregnant women will be included as Cases and controls. Pre-eclampsia will be diagnosed according to clinical findings of increased blood pressure (>=140 mm Hg systolic blood pressure [SBP] or >=90 mm Hg diastolic blood pressure [DBP] on two or more measurements at least 6 h apart) and proteinuria >=0.3 g/24 h or >= +1 on a urine dipstick after 20weeks of gestation.

Exclusion criteria

Exclusion criteria: Women with twins or multiple pregnancies, hydatidiform mole, hydrops fetalis, diabetes, renal disease, liver dysfunction, systemic lupus erythematosus and all systemic diseases will be excluded from the study. History of preexisting hypertension will also be exclusion criteria for both cases and controls.

Design outcomes

Primary

MeasureTime frame
Pre-eclampsia and Complications of Pre-eclampsiaTimepoint: Risk factor and outcome will be measured at the time of contact with the patient

Secondary

MeasureTime frame
Role of vascular endothelial injury/dysfunction in the pathophysiology of complication related to pre-eclampsia.Timepoint: Risk factor and outcome will be measured at the time of contact with the patient

Countries

India

Contacts

Public ContactAnubhuti Chitkara

Maulana Azad Medical collage

anubhuti1234@rediffmail.com9999323592

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026