Role of Alpha agonists in relief of labour pain

A comparison bwtween levobupivacaine with Dexmedetomidine versus levobupivacaine with clonidine in labour analgesia

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/10/028645

Enrollment

Registered

2020-10-26

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O80- Encounter for full-term uncomplicated delivery

Interventions

Intervention1: Patient controlled epidural analgesia for labour: Comparision of dexmedetomidine and clonidine as adjuvants with levobupivacaine with an initial bolus of 10ml followed by patient contro

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I,II Full terrm Primigravida Singleton pregnancy with vertex presentation

Exclusion criteria

Exclusion criteria: Pre-eclampsia, eclampsia Thyroid disease Diabetes Heart disease Twin pregnancy

Design outcomes

Primary

Measure	Time frame
compare Analgesic efficacy of dexmedetomidine and clonidine based on VAS scoreTimepoint: VAS At 0, 5, 10 15, 30, 45, 60 minutes and then every half hour until delivery	—

Secondary

Measure	Time frame
Compare motor effect by Bromage scoreTimepoint: At 0, 5, 10 15, 30, 45, 60 minutes and then every half hour until delivery;Haemodynamic effects- Heart rate, systolic BP, diastolic BP, mean arterial pressure, spo2Timepoint: At 0, 5, 10 15, 30, 45, 60 minutes and then every half hour until delivery;Maternal side effectsTimepoint: At end of labour;Neonatal outcome, Apgar scoreTimepoint: At 1 and 5 minutes after delivery;Time of onset of analgesia, quality of analgesia, nature of Expulsive efforts, Type of deliveryTimepoint: At end of delivery	—

Measure

Time frame

Compare motor effect by Bromage scoreTimepoint: At 0, 5, 10 15, 30, 45, 60 minutes and then every half hour until delivery;Haemodynamic effects- Heart rate, systolic BP, diastolic BP, mean arterial pressure, spo2Timepoint: At 0, 5, 10 15, 30, 45, 60 minutes and then every half hour until delivery;Maternal side effectsTimepoint: At end of labour;Neonatal outcome, Apgar scoreTimepoint: At 1 and 5 minutes after delivery;Time of onset of analgesia, quality of analgesia, nature of Expulsive efforts, Type of deliveryTimepoint: At end of delivery

—

Countries

India

Contacts

Public ContactShruti kabi

Department of Anesthesiology, KGMU

dineshkgmu@yahoo.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026