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For the patients undergoing TURP (A laproscopic surgery for reducing the size the prostate) for which spinal anaesthesia is given. We are giving ephedrine (a vasopressor) which will reduce the incidence of decrease in blood pressure which is the side effects of spinal anaesthesia.

To evaluate the effect of ephedrine in preventing hemodynamic derangements in patients undergoing TURP under spinal anaesthesia: A randomised controlled study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/10/028619
Enrollment
124
Registered
2020-10-26
Start date
Unknown
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N99- Intraoperative and postproceduralcomplications and disorders of genitourinary system, not elsewhere classified

Interventions

Intervention1: To evaluate the effect of ephedrine in preventing hemodynamic derangements in patients undergoing TURP under spinal anaesthesia: A randomised controlled study.: All the diagnosed BPH p

Sponsors

Department of Anaesthesia
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA I , II 2. Diagnosed case of BPH age 40-90 years scheduled for TURP 3. Locally advanced CA prostate with refractory urinary retention scheduled for TURP.

Exclusion criteria

Exclusion criteria: 1. Patients’ refusal or any contraindication for spinal anaesthesia 2. Severe cardiac disease graded as NYHA class III – IV. 3. Patients with the history of coagulopathy. 4. Patients with closed angle glaucoma, pheochromocytoma, idiopathic hypertrophic subaortic stenosis. 5. Patients on MAO inhibitors and linezolid. 6. Patients with tachyarrhythmias and associated cardiac conditions.

Design outcomes

Primary

MeasureTime frame
The effect of ephedrine in preventing hemodynamic derangements in patients undergoing TURP under spinal anaesthesia that whether its helps in preventing the fall in blood pressure, bradycardia etc. intaoperatively . Timepoint: Intraoperative monitoring of hemodynamic parameters at time intervals as follows: 0 min- 2 min- 5 min -10 min -15 min- 20 min- 25 min -30 min- 40 min- 50 min- 60 min -70 min- 80 min- 90 min—

Secondary

MeasureTime frame
Additional use of any vasopressor (mephentramine) and anticholinergic (atropine). And incidence of other side effects of ephedrine are noticed.Timepoint: 1-2 hours after the surgery—

Countries

India

Contacts

Public ContactShelly Rana

Indira Gandhi Medical College

shwetamahajan437@gmail.com9418040187

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026