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A study to find the role of N acetyl cysteine given intraductally in the submandibular gland on reducing radiotherapy related side effects such as swallowing difficulties and voice changes in patients with oropharyngeal cancer undergoing radiotherapy.

A pilot study to assess the effect of intraductal N acetyl cysteine on swallowing and voice outcomes of patients with oropharyngeal cancer undergoing radiotherapy.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/10/028521
Enrollment
20
Registered
2020-10-21
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C10- Malignant neoplasm of oropharynx

Interventions

Intervention1: Intraductal instillation of N acetyl cysteine/saline in bilateral whartons duct.: 3-5 ml of 2% NAC will be given as bilateral instillation in the duct of submandibular salivary gland be

Sponsors

ENT Department
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Clinically, radiologically and biopsy proven cases of oropharyngeal cancer, 2.Planned for radical radiotherapy, 3.Patients giving written informed consent

Exclusion criteria

Exclusion criteria: 1.Patient not giving consent, 2. 70 years, 3.Decreased mouth opening (Trismus), 4.Having undergone a total laryngectomy, 5.History of radiotherapy in Head and Neck area

Design outcomes

Primary

MeasureTime frame
Change in swallowing using Fibre-optic endoscopic evaluation of swallowing (FEES) and M.D. Anderson Dysphagia Inventory (MDADI) score. Changes in voice using Voice Handicap Index-10 (VHI-10) score. Timepoint: 0, 3 months—

Secondary

MeasureTime frame
Change in the salivary flow rate, pH and viscosity.Timepoint: 0, 3 months—

Countries

India

Contacts

Public ContactDr Arvind Kumar Kairo

AIIMS

arvindkairo@yahoo.com9868397441

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026