To know which of the two drugs ketamine or dexamethasone are better in reducing sore throat in patients after undergoing surgery in complete unconsciousness if they are nebulized with either of the drugs before surgery.

To compare the effect of preoperative ketamine nebulization with dexamethasone nebulization on postoperative sore throat in patients undergoing general anaesthesia requiring endotracheal intubation

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/10/028497

Enrollment

150

Registered

2020-10-20

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K35- Acute appendicitis Health Condition 2: K80-K87- Disorders of gallbladder, biliary tract and pancreas Health Condition 3: K55-K64- Other diseases of intestines

Interventions

Intervention1: Preoperative ketamine nebulization in patients requiring general anaesthesia with orotracheal intubation: Preoperatively, patients will be nebulized with ketamine 50 mg (1.0 ml) in 4 ml

Eligibility

Inclusion criteria

Inclusion criteria: Patients belonging to ASA Grade I and II, undergoing surgery of less than 2 hours duration in supine postion, under genral anaesthesia requiring orotracheal intubation

Exclusion criteria

Exclusion criteria: Patients with hsistory of sore throat or recent upper airway infection, respiratory disease, requiring oral or head and neck surgeries, pregnant females, patients with anticipated difficult airway (mallampatti class 3 and 4), allergy to any of the study drugs or on chronic medication (NSAIDS, Steroids)

Design outcomes

Primary

Measure	Time frame
To compare the incidence of postoperative sore throat at 4h, in adult patients receiving preoperative ketamine nebulization or dexamethasone nebulization, undergoing general anaesthesia requiring endotracheal intubationTimepoint: 4 hours	—

Secondary

Measure	Time frame
To assess postoperative cough and hoarseness if any.Timepoint: NIL;To assess the incidence of postoperative sore throat at 0, 2, 6, 12 and 24 h, in adult patients receiving preoperative keatmine nebulization or dexamethasone nebulization, undergoing general anaesthesia requiring endotracheal intubation.Timepoint: 0, 2, 6, 12, 24 hours;To assess the severity of postoperative sore throat at 0, 2, 4, 6, 12 and 24 hTimepoint: 0, 2, 4, 6, 12, 24 hours	—

Measure

Time frame

To assess postoperative cough and hoarseness if any.Timepoint: NIL;To assess the incidence of postoperative sore throat at 0, 2, 6, 12 and 24 h, in adult patients receiving preoperative keatmine nebulization or dexamethasone nebulization, undergoing general anaesthesia requiring endotracheal intubation.Timepoint: 0, 2, 6, 12, 24 hours;To assess the severity of postoperative sore throat at 0, 2, 4, 6, 12 and 24 hTimepoint: 0, 2, 4, 6, 12, 24 hours

—

Countries

India

Contacts

Public ContactDr Parul Mullick

VMMC & Safdarjung Hospital

parash93@yahoo.com9810606262

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026