Health Condition 1: - Health Condition 2: K802- Calculus of gallbladder without cholecystitis
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Drug combination of propofol-dexmedetomidine will be used in one group of patients and hemodynamic variables and recovery characteristics will be observed in pat
Sponsors
Jawaharlal Nehru hospital and research centre
Eligibility
Inclusion criteria
Inclusion criteria: ASA I and ASA II Both genders Age from 18 years to 60 years Patients undergoing laparoscopic cholecystectomy
Exclusion criteria
Exclusion criteria: Age below 18 years and above 60 years ASA III and ASA IV Pregnant or breast - feeding patient Patients with baseline heart rate less than 55/minute Patients with hypertension, heart blocks and ischemic heart diseases Allergic to study drugs Laparoscopic cholecystectomy converted to open cholecystectomy Patient with severe hepatic, renal, endocrine and cardiac dysfunction Patient refusal to participate in the study Patients on sedatives, psychiatric medications, opioid therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Which among the two drug combination has better hemodynamic stability and recovery characteristics. Comparison in terms of Intraoperative hemodynamic variables including heart rate , mean arterial blood pressure , systolic blood pressure, diastolic blood pressure and Recovery characteristicsTimepoint: Intraoperative heart rate , mean arterial blood pressure , systolic blood pressure, diastolic blood pressure measured every 10 mins interval . Recovery characteristics including emergence time, response to commands time, orientation time, Ramsay sedation score at 0min 30 min 60 min 90 min 120 min; VAS score at 0 hour ,1 , 2, 3, 4, 6, 8,10, 12, 18, 24th hour; first analgesic time; recovery discharge | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamics , Recovery profile, post operative analgesic requirement, PACU stayTimepoint: Intraoperative hemodynamic variables like heart rate , mean arterial blood pressure every 10 mins interval . Recovery characteristics including emergence time, response to commands time, orientation time, Ramsay sedation score at 0min 30 min 60 min 90 min 120 min; VAS score at 0 hour ,1 , 2, 3, 4, 6, 8,10, 12, 18, 24th hour; first analgesic time; recovery discharge | — |
Countries
India
Contacts
Public ContactVineeta Dwivedi
Jawaharlal Nehru hospital and research centre
Outcome results
None listed