Health Condition 1: G938- Other specified disorders of brain
Conditions
Interventions
Intervention1: Resveratrol-Copper: R-Cu therapy will be administered four times a day. It will be started atleast 10 days before the surgery and will be given for12 days after the surgery.
Sponsors
Tata Memorial Centre TMC
Eligibility
Inclusion criteria
Inclusion criteria: Radiologic suspicion of GBM on MRI brain (As per discussion in the Tumor Board meetings) 2. Adults - Age above 18 years 3. KPS > 70 4. Planned for Debulking Surgery and adjuvant treatment at Tata memorial centre 5. Adequate hepatic, renal, and hematologic function at baseline 6. Patients who have given written informed consent
Exclusion criteria
Exclusion criteria: Multifocal disease / disease not amenable to complete resection 2. Any prior treatment for cancer â?? surgery, chemotherapy or radiotherapy 3. Past history of cancer 4. Uncontrolled medical comorbidities like hypertensive, diabetes mellitus 5. Seropositivity: HbsAg, HCV, HIV positive, etc. 6. Presence of metastases 7. Patients taking alternative/ complementary treatments
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate changes in OS at 2 years in GBM patients who receive oral R-Cu therapy during the peri-operative treatment phase.Timepoint: 2 years | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To evaluate changes in PFS in GBM patients who receive R-Cu therapy during the peri-operative treatment phase. 2. To evaluate if peri-operative R-cu therapy will down-regulate cancer hallmarks Timepoint: 1 YEAR | — |
Countries
India
Contacts
Public ContactDr Aliasgar V Moiyadi
Tata Memorial Centre TMC
Outcome results
None listed