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A clinical trial to study the effects of Leukocyte platelet rich fibrin (blood concentrate) on orthodontic tooth movement.

Effects of autologous Leukocyte platelet rich fibrin (L-PRF) on rate of maxillary canine retraction during comprehensive orthodontic treatment: A randomized split mouth comparative study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/10/028463
Enrollment
18
Registered
2020-10-19
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R688- Other general symptoms and signs

Interventions

Intervention1: Leukocyte Platelet rich fibrin (L-PRF): Leukocyte platelet rich fibrin (L-PRF) placement followed by extraction of upper 1st premolar on experimental side. Control Intervention1: No ac

Sponsors

All India Institute of Medical Sciences Bhubaneswar
Lead Sponsor
Dr Ashok Kumar Jena
Collaborator
Dr Jitendra Sharan
Collaborator
Dr Manaswini Mangaraj
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Female subjects having Class I bimaxillary protrusion malocclusion with normodivergent growth pattern (FMA, 200-250),minimum crowding or spacing in maxillary and mandibular arches, and require all 1stpremolarextraction for the correction of her malocclusion.Presence of full complement of teeth except 3rd molars.Good oral hygiene (Probing depth

Exclusion criteria

Exclusion criteria: History of previous orthodontic treatment, Subject who fails to maintain good oral hygiene during orthodontic treatment, Subjects with pregnancy, Subjects having any known syndrome or metabolic disorder affecting calcium and phosphate metabolism, Medication like NSAIDs, Lack of manual dexterity, Having medications for any systemic disease, Known blood disorder like thrombocytopenia, leukopenia etc.

Design outcomes

Primary

MeasureTime frame
Acceleration of orthodontic treatmentTimepoint: prior to premolar extraction(T0), after 4 weeks after premolars extraction (T1), 8-weeks (T2), 12-weeks (T3) and 16-weeks (T4) after premolar extraction.—

Secondary

MeasureTime frame
Associated elevation of expression of IL-1β and TNF-α in gingival crevicular fluid distal to canines on experimental and control sideTimepoint: prior to premolar extraction(T0), after 4 weeks after premolars extraction (T1), 8-weeks (T2), 12-weeks (T3) and 16-weeks (T4) after premolar extraction.—

Countries

India

Contacts

Public ContactDr Ashok Kumar Jena

AIIMS, Bhubaneswar

dent_ashok@aiimsbhubaneswar.edu.in9438884077

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026