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A clinical trial to study the effects of Leukocyte platelet rich fibrin (blood concentrate) on orthodontic tooth movement.

Effects of autologous leukocyte platelet rich fibrin (L-PRF) on the expression of RANKL and OPG during comprehensive orthodontic treatment: A randomized split mouth comparative study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/10/028390
Enrollment
18
Registered
2020-10-13
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R688- Other general symptoms and signs

Interventions

Intervention1: Leukocyte platelet rich fibrin (L-PRF): Leukocyte platelet rich fibrin (L-PRF) will be placed immediately after the extraction of upper 1st premolar on experimental side Control Interve

Sponsors

AIIMS Bhubaneswar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Subjects having Class I bimaxillary dentoalveolar protrusion malocclusion or Class II div 1 malocclusion with Normo divergent growth pattern (FMA, 200-250). 2. Minimum crowding or spacing in maxillary arch. 3. Requiring maxillary 1st premolars or, all 1st premolar extraction for correction of malocclusion. 4. Presence of full complement of teeth except 3rd molars. 5. Good oral hygiene (probing depth of

Exclusion criteria

Exclusion criteria: 1. History of previous orthodontic treatment. 2. Subject who fails to maintain good oral hygiene during orthodontic treatment. 3. Subjects with pregnancy. 4. Subjects having any known syndrome or metabolic disorder affecting calcium and phosphate metabolism. 5. Medication like NSAIDs. 6. Lack of manual dexterity. 7. Having medications for any systemic disease. 8. Known blood disorder like thrombocytopenia, leukopenia etc. 9. Patient not ready to give consent for the procedure.

Design outcomes

Primary

MeasureTime frame
Elevation of expression of RANKL and OPG in gingival crevicular fluid distal to canines on experimental and control side, prior to premolar extraction(T0), after 4 weeks after premolars extraction (T1), 8-weeks (T2), 12-weeks (T3) and 16-weeks (T4) after premolar extraction.Timepoint: RANKL and OPG in GCF will be estimated at an interval of 4 weeks—

Secondary

MeasureTime frame
Accleration of orthodontic tooth movementTimepoint: prior to premolar extraction(T0), after 4 weeks after premolars extraction (T1), 8-weeks (T2), 12-weeks (T3) and 16-weeks (T4) after premolar extraction.—

Countries

India

Contacts

Public ContactDr Ashok Kumar Jena

AIIMS, Bhubaneswar

dent_ashok@aiimsbhubaneswar.edu.in9438884077

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 11, 2026