Health Condition 1: C509- Malignant neoplasm of breast of unspecified site
Conditions
Interventions
Intervention1: Sentinel Lymph node biopsy by fluorescein and methylene blue: In the fluorescein and methylene blue arm, one ml of 20% fluorescein diluted with 4 ml of normal saline will be injected in
Sponsors
AIIMS Jodhpur
Eligibility
Inclusion criteria
Inclusion criteria: 1. Post NACT, node negative breast cancer patients who are planned for surgery 2. Those who are accepted to participate in the study and gives consent 3. Between 18 and 90 years of age. 4. ECOG performance status 0-1
Exclusion criteria
Exclusion criteria: 1. Prior surgical procedures that have the potential to substantially alter the lymphatic drainage pattern from the primary tumor to the lymph node basin. 2. Allergy to fluorescein /methylene blue 3. Pregnant or lactating women 4. Renal failure / Renal parenchymal disease patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -SLN Identification rate and false negative rate by using fluorescein and methylene blue in comparison to methylene blue aloneTimepoint: 1) during intraoperative time (baseline) 2) whenever final biopsy is ready ( approximately 10 days) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Impact of Preoperative axillary ultrasonography of axilla in decision making for sentinel lymph node biopsyTimepoint: postoperative period ( 15 days) | — |
Countries
India
Contacts
Public ContactByshetty Rajendar
AIIMS , JODHPUR
Outcome results
None listed