Comparing two new methods of providing anesthesia for patients undergoing operation without use of opioid medication.

A randomised controlled double blind study to compare ketamine-dexmedetomidine versus ketamine-propofol combinations for opioid free anaesthesia in patients undergoing brachial plexus injury repair.

Status

Recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/10/028305

Enrollment

Registered

2020-10-08

Start date

Unknown

Completion date

Unknown

Last updated

2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G540- Brachial plexus disorders

Interventions

Intervention1: Dexmedetomidine: Induction:intravenous dexmedetomidine 1 mcg/kg over 10 minutes slow infusion at beginning of anesthesia Maintainance: intravenous dexmedetomidine 0.5 mcg/kg/hr thro

Eligibility

Inclusion criteria

Inclusion criteria: Undergoing brachial plexus injury repair under general anesthesia ASA I or II

Exclusion criteria

Exclusion criteria: High risk coronary or vascular disease Patient on beta blockers Hepatic dysfunction Eye globe injuries Increased intracranial pressure Increased intraocular pressure History of psychosis Uncontrolled hypertension

Design outcomes

Primary

Measure	Time frame
Requirement of additional analgesic intraoperativelyTimepoint: Baseline and postoperatively	—

Secondary

Measure	Time frame
Post operative sedation levelTimepoint: Post operative sedation level;Post-operative pain scoreTimepoint: 15 min, 30 min, 1 hr, 2 hr, 4hr, 6 hr, 12 hr, 18 hr, 24hr;Time to achieve modified Aldrete score 9Timepoint: 10 min, 20 min, 30 min, 40 min, 50 min, 60 min;Time to first rescue analgesiaTimepoint: Time to first dose;Total analgesic requirement in first 24 hoursTimepoint: First 24 hours	—

Countries

India

Contacts

Public ContactVeparala prudhvi raj

PGIMER

drvsaini@gmail.com7087008119

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026