Health Condition 1: K053- Chronic periodontitis
Conditions
Interventions
Control Intervention1: Not Applicable: Not Applicable
Sponsors
Roshan R Rughwani
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria common to all groups: 1.Age range: >=35. 2.Non Smoker. Based on 2017 World Workshop on the Classification of Periodontal and Peri-implant diseases and conditions, co-presented by the American Academy of Periodontology (AAP) and the European Federation of Periodontology(EFP), Inclusion criteria for periodontally healthy individuals: According to the new classification scheme (Kornman and Tonetti et al, 2018). 1.Pristine periodontal health(No bleeding on probing,Normal gingival sulcus depth,Normal bone heights,Controlled modifying factors,Controlled predisposing factors. 2.Clinical periodontal health (intact periodontium):No or minimal bleeding on probing,Normal gingival sulcus depth,Normal bone heights,Controlled modifying factors,Controlled predisposing factors. Inclusion criteria for Stage III/IV Periodontitis: According to the new classification scheme (Kornman and Tonetti et al, 2018). 1.Stage III:Interdental clinical attachment loss at site of greatest loss >= 5mm,Radiographic bone loss extending to middle or apical third of root,Tooth loss due to periodontitis = 6mm,Extent: Greater than 30% of teeth involved (Generalized) 2.Stage IV:Interdental clinical attachment loss at site of greatest loss >= 5mm,Radiographic bone loss extending to middle or apical third of root,Tooth loss due to periodontitis >= 5 teeth,Extent: Greater than 30% of teeth involved (Generalized) Inclusion criteria for Atherosclerotic patients: 1.History of angina 2.Angiography revealing a block. 3.Raised serum LDL and triglyceride levels LDL Cholesterol Level: 160 to 189 mg/dl (High) >190 mg/dl (Very High) Total Cholesterol Level: greater than 240 mg/dl Non HDL Cholesterol level above 159 mg/dl Triglyceride levels : 200 to 499 mg/dl (High) Above 500 mg/dl(Very High)
Exclusion criteria
Exclusion criteria: 1. Patients with immunodeficiency disorders. 2. Patients with other systemic inflammatory conditions like sepsis, pneumonia, pleural effusion, intra-abdominal infections, inflammatory bowel disorders, inflammatory rheumatoid disorders, chronic kidney disease, cancers, diabetes, COPD, asthma, HIV and hepatitis will be excluded from the study. 3. History of periodontal treatment within the previous 6 months. 4. History of antibiotic therapy in the past 3 months. 5. History of consumption of antihypertensive medications - calcium channel blockers. 6. Subjects who are not willing to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Compare and correlate the levels of PCSK9 And IL-6 in the serum and saliva of patients with STAGE III/IV periodontits and atherosclerotic plaque patients. Timepoint: At Baseline Only | — |
Secondary
| Measure | Time frame |
|---|---|
| NilTimepoint: Nil | — |
Countries
India
Contacts
Public ContactPriyanka K Cholan
SRM Dental College, Ramapuram
Outcome results
None listed